She was constitutionally appointed to the office following the resignation of Ricardo Roselló, and the judicial annulation of Pedro Pierluisi's short-lived government in the aftermath of the Telegramgate Scandal.

On August 16, 2020, she failed to secure the New Progressive Party nomination for Governor of Puerto Rico in the 2020 elections, losing to Pedro Pierluisi.

On August 4, 2022, Vázquez was arrested by the FBI, on charges of corruption, over a bribery case connected to her 2020 gubernatorial campaign; she had demanded the Commissioner of Financial Institutions to resign.

She began her primary studies at the Ramón Marín and Margarita Janer schools in Guaynabo, Puerto Rico.

She said in an interview that she used to watch TV shows like Hawaii Five-O with her father, which led her to realize she wanted to follow a career along that line.

[citation needed] In 2010, Vázquez was appointed to replace Ivonne Feliciano as the head of the Office for Women's Rights of the island.

[16][17] She was met with opposition, with critics calling for her resignation due to allegations of corruption and inability to deal with domestic violence on the island.

[27] On August 7, 2019, the Supreme Court of Puerto Rico ruled that Pierluisi was sworn in on unconstitutional grounds and removed him from office, effective at 5 p.m. AST.

[28][29] Vázquez stated she wanted to recover Hurricane Maria relief funds, and review all government contracts to ensure they are managed correctly, free of corruption.

[32] In the aftermath of 2019–20 Puerto Rico earthquakes residents discovered unused aid from Hurricane Maria in a warehouse in Ponce and as a result Vázquez fired her emergency management director.

[33] On July 21, 2020, the Puerto Rico Office of the Special Independent Prosecutor's Panel opened a case against Vázquez for alleged violation of the Commonwealth's ethics law, as well as federal regulations, related to her handling of aid to the earthquake victims.