Subject to a reduction in size, with northern and western areas, including the town of Faringdon, being transferred to Witney, it was reformed as Didcot and Wantage, to be first contested at the 2024 general election.

All have tourist attractions, Wantage having monuments to being the birthplace of King Alfred the Great, Wallingford, ancient enclosure walls of a castle and a medieval bridge.

The largest town in the constituency was Didcot, which grew up around the Great Western Railway when Isambard Kingdom Brunel built a branch line from its main line between London and Bristol to Oxford, siting the junction at the then-sparsely-populated parish and it has a power station and many major national construction and aggregate industries.

Included were the Uffington White Horse and The Ridgeway, a prehistoric road, runs along its southern border.

Workless claimants, registered jobseekers, were in November 2012 significantly lower than the national average of 3.8%, at 1.6% of the population based on a statistical compilation by The Guardian.

The first MP for Wantage was Robert Jackson, who served as a junior minister under both Margaret Thatcher and John Major.

Shortly prior to this, Vaizey had the Conservative whip removed after voting against Prime Minister Boris Johnson on 3 September 2019.