[4] Wapello is part of the Muscatine Micropolitan Statistical Area.

[6] Wapello is located on the west side of the Iowa River.

As of the census of 2020,[10] there were 2,084 people, 837 households, and 543 families residing in the city.

There were 900 housing units at an average density of 718.6 per square mile (277.5/km2).

Hispanic or Latino persons of any race comprised 10.1% of the population.

There were 889 housing units at an average density of 689.1 per square mile (266.1/km2).

28.6% of all households were made up of individuals, and 14.3% had someone living alone who was 65 years of age or older.

There were 893 housing units at an average density of 709.8 per square mile (274.1/km2).

27.2% of all households were made up of individuals, and 15.1% had someone living alone who was 65 years of age or older.