[5] New to the series is the concept of magic and Sacred Treasures, techniques that allow characters to perform special feats to overcome enemies.

These depend on a specific category that is separate from the class system, and are performed by holding down the right shoulder button and pressing either the normal, charge, or musou attack buttons, the latter two requiring a special magic gauge, and the last also requiring half of a player's musou gauge.

The Awakening mechanic from Dynasty Warriors 8 and Musou Gokui mechanic from Samurai Warriors 4 are unified in Warriors Orochi 4, and may only be activated by obtaining a rare powerup during gameplay and pressing the left analog stick; when playing with only a single Joy-Con on the Nintendo Switch, this is instead activated by pressing both SL and SR, as the left analog stick alone is normally mapped to the character switch functionality.

[7] Following the events of Warriors Orochi 3, the heroes of the Three Kingdoms and Sengoku period return to their time, having forgotten all their exploits in the dimensional world.

Perseus leads the first one, which includes Naotora Ii, Guan Yinping, and Yukimura Sanada, each controlling the power of Aphrodite, Freya, and Tyr, respectively.

The third is led by Zeus' children, Ares and Athena, and includes Zhao Yun, Mitsunari Ishida, and Cao Pi, each controlling the power of Apollo, Hermes, and Poseidon, respectively.

Yukimura forms a bond with Perseus, while Ares is revealed to have earned the loyalty of Cao Pi and Hideyoshi Toyotomi, whom he mistakenly thinks is a bracelet wielder, by promising them worldly power, but they realize that he has no intention of keeping it.

Perseus eventually unmasks himself as Loki, a servant of Odin, the king of Asgard, who secretly leads Da Ji's faction.

He deliberately scattered the bracelets so the heroes could channel their godly power, therefore stabilizing the world enough for Odin to enact his plan: summoning the God of Destruction, the world's will taking the form of Orochi, so he can grow Yggdrasil and create a weapon powerful enough to destroy the universe and start it with a clean slate.

When the heroes finally defeat Zeus, who admits that he only wanted to spar with them, Ares snaps and kills him, absorbing his power and declaring himself the new king of Olympus.

Throughout the campaign, Loki admits that Perseus' soul was shattered when he killed him, giving Gaia an idea to gather them all so they may be able to resurrect him.

The battle with Hades done, Loki, the Olympians, and the Mystics bid the heroes farewell before returning them back to their world.

School Idol Project series,[9] a re-arranged version of a track from her fourth studio album Tone, made specifically for this game.

The Ultimate version has a music as well named "Statice" by Saori Hayami, who previously voiced Miyuki Shiba from The Irregular at Magic High School, Shirayuki from Snow White with the Red Hair, Himawari Uzumaki from Boruto: Naruto Next Generations and others.

The PlayStation 4 and Switch ports of the game sold 124,836 and 30,682 physical retail copies, respectively, within their first two weeks of release in Japan.