Wasena is a Roanoke, Virginia (United States) neighborhood located in south, central Roanoke bisected by U.S. Route 221 (Main Street), immediately to the south of the Roanoke River.

It borders the neighborhoods of Raleigh Court on the west, Old Southwest on the north and east and Mountain View via the Wasena Bridge across the Roanoke River on the north, and Franklin-Colonial on the south.

[1] As of the 2000 U.S. Census, Wasena has a population of 1,633 residents.

[1] Taking its name from the Native American word meaning "beautiful view," Wasena was annexed into the city in 1919 and began its development as an early suburb of Roanoke in the 1920s.

The architecture of the area is varied with the largest numbers representing both the American Craftsman Bungalow and American Foursquare design for residential construction.