Water polo competitions at the 2022 South American Games in Asunción, Paraguay were held from 11 to 15 October 2022 at the Centro Acuático Nacional cluster.

[1] The gold and silver medalists teams in each tournament qualified for the 2023 Pan American Games water polo competitions, plus Chile which qualified automatically as the 2023 Pan American Games hosts.

[2] Argentina and Brazil were the defending champions of the South American Games men's and women's water polo events.

[3] A total of 8 ODESUR nations registered teams for the water polo events.

[1] Argentina, Brazil, Chile, Colombia and hosts Paraguay participated in both men's and women's tournament.