Khupe attended the National University of Science and Technology, where he received a Master of Business Administration degree.

In 1990, Khupe founded the Muscular Dystrophy Association of Zimbabwe, and from 2011 to 2015, he served as the organization's project manager.

[5][6] This is a specially allotted constituency, in which the one male and one female senator are elected by an electoral college open to delegates from registered disabilities organizations.

[8] Khupe advocated for expanding access to braille reading material, urging companies to employ people with disabilities, and an increased usage of sign language in schools.

Khupe died on 17 July 2022 at Mater Dei Hospital in Bulawayo from complications caused by his muscular dystrophy.