Wauseon was platted 1853 when the Michigan Southern Air Railway was extended to that point.

[9] However, Hortensia Hayes, the daughter of an early settler, suggested that the new village be named after an Ottawa Tribe Chief named Wauseon, who was forced by the federal government to forfeit their land, before moving to Oklahoma in 1839.

The construction of the Ohio Turnpike in the mid 20th century also helped lead to the commercial growth of Wauseon.

26.6% of all households were made up of individuals, and 10.7% had someone living alone who was 65 years of age or older.

26.0% of all households were made up of individuals, and 10.6% had someone living alone who was 65 years of age or older.

[29] Wauseon Public Library was originally funded by tycoon and entrepreneur Andrew Carnegie in 1906.

The library temporarily moved out to the former location of Bill's Lockeroom on Shoop Avenue until mid April 2017 before moving back in to the original library building on Elm Street.

[31][32] The community is served by the Fulton County Expositor, an AIM Media Midwest newspaper.

[33] Fulton County Health Center is a rural critical access hospital that includes an emergency department with a heliport for medical evacuation.