Brought up in the LDS Church, he rebelled against his parents' wishes that he serve as a missionary and moved to Liverpool in the late 1970s to join the scene around Eric's Club, a noted nightclub of the time.

After Burns retreated to become more studio-based, Hussey decided to leave and was offered a position with the Sisters of Mercy, concentrating on twelve-string and six-string guitars, contributing to arrangements and using his higher ranged voice for backing vocals which contrasted with Andrew Eldritch's melancholic baritone.

After leaving the Sisters of Mercy, Hussey and bassist Craig Adams set up the Mission, recruiting Mick Brown on drums and Simon Hinkler on guitars.

supporter and after his team's victory in the Champions League Final of 2005, he composed the song entitled "Draped in Red" featured on the studio album God Is a Bullet.

After he wound up the Mission for the second time in early 2009, he released his first solo studio album called Bare in October of that year on the Sony Music label.

On this project Wayne collaborated with friends and musicians, including Michael Ciravolo, Andy Rourke of the Smiths, Billy Duffy of the Cult, Budgie of Siouxsie and the Banshees, Evi Vine, Gary Numan, James Alexander Graham of the Twilight Sad, Jay Aston of Bucks Fizz, Julianne Regan of All About Eve, Kevin Haskins of Bauhaus, Lol Tolhurst of the Cure, Martin Gore of Depeche Mode, Michael Aston of Gene Loves Jezebel, Midge Ure of Ultravox, Miles Hunt of the Wonder Stuff, Rachel Goswell of Slowdive, Richard Fortus of Guns N' Roses, Robin Finck of Nine Inch Nails, Tim Palmer, Trentemøller and Kirk Brandon of Theatre of Hate and Spear of Destiny.