Construction on the school began in 1936, funded by a Public Works Administration grant.

In the spring of 2015, there was an ongoing debate on the future of the building: to rebuild or renovate.

As of 2018, construction began for the renovation and the new additions to Waynesboro High School.

[2] Since 2019, Bryan Stamm has served as Waynesboro High School's principal.

[3] Advanced Placement (AP) classes are offered in English, music, and social sciences.