Built in 1724 and repeatedly enlarged, it was for many years the home of American Revolutionary War general Anthony Wayne (1745–1796).

It is a roughly U-shaped stone structure, the main block 2+1⁄2 stories in height and covered by a gabled roof.

He distinguished himself as a military leader in the American Revolutionary War for his brash and sometimes risky maneuvers, winning him the moniker "Mad" Anthony.

[3] The Waynesborough property remained in the hands of Wayne's direct descendants until 1965, and was in 1980 transferred to a local preservation group.

The Philadelphia Society for the Preservation of Landmarks now manages the property, and offers tours from mid-March through December on Thursday through Sunday.