In the 1860s, the place where Wayville now stands was a milk run rented from the South Australian Company.

In the 1870s, King William Street was extended south through the Park Lands and Unley; this continues to form the eastern boundary of the suburb.

Wayville Military Post Office was open from 16 July 1940 until 19 October 1946 while the Showgrounds were used as an army camp.

[4] The Latvian Hall[5] or Talava (old mountain castle), located at 4 Clark Street in Wayville, was established in 1966.

The hall is rented out to the community, and is supported by the Latvian Chamber of Commerce and Industry in Australia Inc. (LCCIA).

The St Michael the Archangel Church is part of the Roman Catholic (Latin Rite) Society of St. Pius X.

The "Amphi Cosma" house in Young Street[11][12] was built in 1914 by the noted Adelaide master builder Walter C. Torode for his own use.

The Alliance Française d’Adelaide at 319 Young Street is an Australian not-for-profit association set up to promotion French language and culture.

Fusion Business Solutions was founded by Marc Brien and his wife Karen in July 1999.

[14] Central Queensland University Appleton Institute is a multidisciplinary research hub located at 44 Greenhill Road.

It consists of two fully furnished comfortable and inexpensive 1 bedroom maisonettes, and provides easy access to medical, government, and education services.