After a one-off show on January 31, 2020, in Miami in conjunction with Super Bowl LIV, the band was slated to tour Central and South America in March and April.

[6] The first tour date took place as scheduled on March 14, 2020, in Mexico City as part of the Vive Latino Festival (where they played "So Fine" with Duff McKagan on vocals for the first time since 1993), in spite of the rapid advance of the COVID-19 pandemic.

On May 11, 2020, the band announced on Twitter that the European leg of the tour, which was originally scheduled to begin on May 20 in Lisbon, Portugal, had been cancelled.

On August 3, 2021, at Fenway Park in Boston, the band played "Absurd", a reworking of the song "Silkworms" from the Chinese Democracy sessions, performed live four times back in 2001.

According to figures reported to Billboard Boxscore, the U.S. leg of the Guns N' Roses 2021 Tour grossed $50 million and sold 363,000 tickets.