Akon, T.I., Rick Ross, Fat Joe, Baby, and Lil Wayne are all featured on this hip hop track.

Nate "Danja" Hills assisted the artists in writing the song and is also the producer.

Cameos in the video are made by Pitbull, Bun B, Junior Reid, DJ Infamous, Freeway, Triple C's, Dolla, Johnny Dang, T-Pain, Trina, Curren$y, and Cool & Dre among others.

VIBE selected Lil Wayne's guest appearance in "We Takin' Over" to be his best of 2007, ranking the song at No.

Female rappers Trina, Remy Ma and Jacki-O, and singers Lil' Mo, and DJ Lazy K recorded a remix for Remy Ma's mixtape, Shesus Khryst, which was also featured on Trina's mixtape, Rockstarr Royalty, albeit slightly edited.