[8] Situated on land made available to homesteaders as part of the Cheyenne-Arapaho Roundup and Removal on April 19, 1892, Weatherford was incorporated on August 3, 1898, on a townsite location chosen by banking and civic leader Beeks Erick.

Kodak's 50-year old manufacturing plant in Weatherford was subject to a $15 million expansion in 2017 related to flexographic packaging plates.

[14] Weatherford is a hub for multiple oil and natural gas industry leaders such as Oneok Field Services and Chesapeake Energy,[15] as well as a location for wind power production.

[16][17] Aircraft displays include an actual Sopwith Pup, F-86, F-104, T-33, T-38, F-16, and a rare MIG-21, as well as full-scale replicas of the Wright Flyer, Bleriot and Spirit of St.

[18] Weatherford is the hometown of astronaut Thomas P. Stafford, veteran of four space flights and commander of the Gemini 9, Apollo 10 missions and the Apollo–Soyuz project.

[19] The 12,000 square foot building contains many artifacts from the late 1800s through the 1950s in thirty-two major historical exhibits, including a 1931 Model A Ford sports coupe, and features three historic theme buildings (diner, school house, and blacksmith's shop) on the museum grounds.

SWOSU is placed in Tier 2 of the "Regional Universities (West)" category in the 2016 edition of the U.S. News & World Report Education Rankings and offers associate, bachelor's, master's and professional doctorate degree programs.

[25] Western Technology Center (WTC) provides the opportunity for adults and high school students to get occupationally-specific training.

[27] Weatherford was, for many years, situated on a main line of the now defunct Rock Island Railroad, which is still in operation by Farmrail Corporation.

[28] With the advent of the automobile, the city was initially located on State Highway 3 starting in the early 1920s, which was redesignated as U.S. Route 66 in 1926 and paved entirely across Western Oklahoma by 1932.

Interstate 40 was completed east and west of the city in 1960 generally paralleling the old U.S. 66 alignment, which was retained as frontage road.

The Thomas P Stafford Airport (KOJA; FAA ID: OJA), two miles northeast of town, features a 5100’ x 75’ paved runway.