[1] It is based on the web series of the same name and stars Lisa Kudrow as Fiona Wallice, a therapist who works with patients over the Internet.

Kudrow's former Friends costars David Schwimmer, Matthew Perry, Matt LeBlanc and Courteney Cox have all appeared as guest stars on Web Therapy.

Other guest stars that have appeared over the course of the series include: Maulik Pancholy, Steven Weber, Bob Balaban, Jane Lynch, Rosie O'Donnell, Selma Blair, Conan O'Brien, Molly Shannon, Steve Carell, Minnie Driver, Meryl Streep, Julia Louis-Dreyfus, Meg Ryan, Sara Gilbert, Chelsea Handler, Megan Mullally, Mae Whitman, Darren Criss, Billy Crystal, Calista Flockhart, Jon Hamm, Caspar Lee, Gwyneth Paltrow, Dax Shepard, Craig Ferguson, Jesse Tyler Ferguson, Lauren Graham, Nina García, Allison Janney and Christina Applegate.

[5] In April 2010, Showtime announced plans to run the online episodes on television with extra scenes being shot to fit the half-hour format.

Putsy thinks web therapy is a ridiculous waste of time and an embarrassment, and she lets Fiona know it in no uncertain terms.

[18] Jessica Shaw of Entertainment Weekly praised the show's writing: "Lisa Kudrow is hilarious as online shrink Fiona Wallice, but her true talent is making those around her even funnier".

"[20] Mark A. Perigard of The Boston Herald gave the show a positive review during a joint review of Web Therapy and Kudrow's former Friends co-star, Matt LeBlanc's show Episodes, calling it "far more entertaining [than Episodes], but, alas, wildly uneven, probably in part due to the need to weave new material around the Internet series of the same name that spawned it.

Special features include a behind-the-scenes featurette, director cuts with Conan O'Brien and Meryl Streep, an auto-tune music video, deleted scenes, and gag reels.

[29] On 29 August 2017, it was announced that Stephen Mangan would star in and co-write a British adaptation titled Hang Ups for Channel 4 in the United Kingdom.

On 21 October 2015, the Polish version of Web Therapy premiered on Player.pl, with Agata Kulesza playing the lead role of Dr. Lucyna Kole-Bojarska.