It takes its name from a colonial-era ferry landing and connection across the Hudson River to Weehawken, New Jersey.
Over the years, the area's buildings were used for dwellings, stables, boarding houses, maritime-related businesses, transportation-related businesses, clothing and supply stores and other miscellaneous industries, but a dominant use was for saloons and liquor stores, including bars and clubs catering to a "rough trade" gay clientele in the late 20th century.
The architecture illustrates the area's long history as a place of dwelling, industry, and commerce, much of it maritime-related, and is a rare surviving example of this once typical development pattern on Manhattan's west side waterfront.
Many of the properties in the historic district were associated with the families of prominent long-term owners, such as former Mayor Stephen Allen, Cornelius V.S.
Roosevelt, lawyer Edmund R. Terry, brewer-distiller Patrick Skelly, and linen merchant James Dean.