The men's 105 kilograms weightlifting event at the 2012 Summer Olympics in London, United Kingdom, took place at ExCeL London.

In case of a tie, the lighter lifter won; if still tied, the lifter who took the fewest attempts to achieve the total score won.

Lifters without a valid snatch score did not perform the clean and jerk.

Russia's Khadzhimurat Akkaev and Dmitry Klokov were on the start list but did not compete.

[6] On 22 December 2018, it was announced that Ukraine's Oleksiy Torokhtiy, who had originally been the gold medalist, and Uzbek Ruslan Nurudinov, who had originally finished fourth, had tested positive for performance-enhancing drugs.