The women's 53 kilograms weightlifting event at the 2012 Summer Olympics in London, United Kingdom, took place at ExCeL London on 29 July.

In case of a tie, the lighter lifter won; if still tied, the lifter who took the fewest attempts to achieve the total score won.

Lifters without a valid snatch score did not perform the clean and jerk.

[2] The original gold medalist, Zulfiya Chinshanlo of Kazakhstan was disqualified from the Games on 27 October 2016, and her medal, results and records stripped.

Re-analysis of Chinshanlo's samples from London 2012 had resulted in a positive test for the prohibited substances oxandrolone and stanozolol, both anabolic steroids.