[1][2] Nerdy social outcast students Gary Wallace and Wyatt Donnelly of Shermer High School are humiliated by senior jocks Ian and Max for swooning over their cheerleader girlfriends Deb and Hilly.

Humiliated and disappointed at their direction in life and wanting more, Gary convinces the uptight Wyatt that they need a boost in popularity in order to win their crushes away from Ian and Max.

She promptly produces a pink 1959 Cadillac Eldorado convertible to take the boys to a blues dive bar in Chicago, using her powers to procure fake IDs for them.

Lisa realizes that the boys need a challenge to boost their confidence and has a gang of mutant bikers crash the party, causing chaos and terrorizing the guests.

The bikers leave, and the next morning, Chet returns from duck hunting to discover the house in disarray, including a localized snowstorm in his room, and the missile.

Upstairs, Lisa assures them that Chet will soon return to normal, and, realizing that her purpose is complete, tearfully hugs both Gary and Wyatt before de-materializing.

[4] Janet Maslin of The New York Times wrote that "Mr. Hughes shows that he can share the kind of dumb joke that only a 14-year old boy could love.

A wonderful writer-director has taken a cute idea about two teenage Dr. Frankensteins creating a perfect woman by computer and turned it into a vulgar, mindless, special-effects-cluttered wasteland.

[8] Rita Kempley of The Washington Post wrote, "Unbelievably, John Hughes, the maker of Sixteen Candles and The Breakfast Club, writes and directs this snickering, sordid, special effects fantasy, with Kelly LeBrock in a demeaning role as love slave to a pair of 15-year olds.

The website's critics consensus reads, "Hardly in the same league as John Hughes' other teen movies, the resolutely goofy Weird Science nonetheless gets some laughs via its ridiculous premise and enjoyable performances.

Following the same basic plot as the film, the series starred Vanessa Angel as Lisa, Michael Manasseri as Wyatt, John Mallory Asher as Gary, and Lee Tergesen as Chet.

[14] As of 2013[update], Universal Studios was planning a Weird Science remake with original producer Joel Silver returning, and Michael Bacall writing the film.