The Wekiva River system includes the main stem joined by three main tributaries - Rock Springs Run, Blackwater Creek, and the Little Wekiva River - and about 30 contributing groundwater springs.

[5] Wekiwa is the Creek-Seminole word for a spring, but contrary to popular belief that Wekiva means "flowing water",[6] it was actually an alternate spelling used by developers.

[8] The Wekiva River system is located in three counties - Orange, Seminole, and then Lake - with a total drainage basin of 351.113 km2 (135.565 sq mi).

Plans for the development failed (and so did the completion of the road) and the undeveloped land was donated to the state of Florida.

The Wekiva is joined by Seminole County's Sweetwater Creek about 1.2 mi (1.9 km) from the headwater.

Protecting the natural condition of the area helps preserve the water quality of both rivers.

The 15-mile (24 km)-long Little Wekiva River is the only tributary influenced by the areas north and west of urban Orlando.

The St. Johns River Water Management District has worked with the Florida Department of Environmental Protection, the Florida Department of Transportation, the city of Altamonte Springs, Seminole and Orange counties, environmental interest groups and basin residents to find solutions in rehabilitating and protecting the Little Wekiva to minimize its negative impact in the water quality of the Wekiva River.