John Weldon Wyckoff (February 19, 1893 – May 8, 1961) was a professional baseball pitcher.

He played all or part of six seasons in Major League Baseball for the Philadelphia Athletics (1913–16) and Boston Red Sox (1917-18).

Wyckoff attended Bucknell University and began his baseball career Wilmington in the Tri-State League in 1911.

Wyckoff pitched in Game One of the World Series, surrendering a run on three hits and hitting a double in his lone career World Series plate appearance.

In his major league career, Wyckoff posted a 23–34 record with 299 strikeouts and a 3.55 ERA in 573.2 innings pitched.