The arena lies at the southwest corner of the South Philadelphia Sports Complex, which includes Lincoln Financial Field, Citizens Bank Park, and Xfinity Live!.

On January 12, 2025, Comcast Spectacor, Harris Blitzer Sports & Entertainment and the City of Philadelphia announced a deal to replace the Wells Fargo Center with a new $1.3 billion privately financed arena to open by 2031.

[14] During the 2015–16 NBA season for a short time, the 76ers ceased recognizing Wells Fargo's naming rights and referred to the facility exclusively as "The Center", as the institution was not a sponsor of the team.

The Wells Fargo Center logo decal which sat on the 76ers court was in the most minimal text discernible by television cameras, colored in white to blend in with the floor.

(Reportedly, 76ers CEO Scott O'Neil's first idea was to color it with clear-coat paint only visible with UV blacklighting showing the logo during the opening of Sixers games when the arena lights were drawn down; however, the team, after discussion with their lawyers, elected not to do so.)

[19] Wells Fargo Center officially seats 20,318 for NBA and NCAA basketball and 19,541 for NHL hockey[1] and indoor NLL lacrosse.

[20] Wells Fargo Center also set a record for the highest attendances for a college basketball game in the commonwealth of Pennsylvania on January 29, 2017, when Villanova played and defeated Virginia before a crowd of 20,907.

The public address (PA) announcer at Wells Fargo Center for Flyers games is Lou Nolan, who moved with the team from the Spectrum, where he worked since 1972.

It debuted a new kinetic 4K-resolution scoreboard in September 2019 also by ANC Sports, which features two main arrays of outside displays that can expand outwards to a width of 62 feet (19 m), and two 65 foot (20 m) "crown" panels that can be raised and lowered as part of sequences.

In October 2019, center staff removed fans shouting "Free Hong Kong" at a pre-season basketball game between the Philadelphia 76ers and Guangzhou Loong Lions.