The Wells Fargo and Company Express Building is a historic commercial building in the ghost town of Silver Reef, Utah, United States, that is listed on the National Register of Historic Places.

The structure was built by local masons George Brooks and Ira McMullin of local red sandstone, with finished ashlar masonry by Brooks in the front and coursed rubble stone by McMullin on the other three sides.

[2] The Wells Fargo building was used as a mine supply store in the late 19th century, then for a time as the residence of the Colbath family.

Its last use was as offices for the Western Gold and Uranium Company, who added a rear porch structure.

[1] It has been restored and is operated as a museum by Washington County as part of the Wells Fargo Silver Reef Monument.