Wellsville is a borough in York County, Pennsylvania, United States.

Wellsville changed very little visually during the twentieth century; the borough's appearance has remained that of a nineteenth-century community, complete with brick sidewalks and Gothic Revival and Greek Revival houses.

[3] Among the district's 48 contributing properties are an 1850s Methodist church, a small group of nineteenth-century commercial buildings, and the Wellsville House, an 1870s structure that has been used as a factory, museum, and restaurant.

[5] According to the United States Census Bureau, the borough has a total area of 0.1 square miles (0.26 km2), all land.

The racial makeup of the borough was 97.13% White, 1.43% African American, 1.08% Asian, and 0.36% from two or more races.