Werle (or Wenden) was a fiefdom in the Holy Roman Empire that was founded in 1235.

The Fiefdom of Werle lay in the area around Güstrow in today's Mecklenburg-Western Pomerania, Germany, and stretched eastward to Müritz.

It was named after the then-capital Werle, now a village in the municipality Kassow, Rostock district.

With the death of the William, the last lord on September 7, 1436, the fiefdom once again reverted to Mecklenburg.

The title of Lord of Werle was thenceforth carried by all rulers of Mecklenburg.