Wertsville is an unincorporated community located along County Route 602 (Wertsville Road) in East Amwell Township of Hunterdon County, in the U.S. state of New Jersey.

By 1881, Wertsville had a school, Baptist church, post office, store, shoemaker shop and wagon shop.

[3] The Wertsville Historic District is a 284-acre (115 ha) historic district encompassing the community along Wertsville and Lindbergh roads.

It was added to the National Register of Historic Places on October 5, 2000 for its significance in architecture, commerce, and community planning and development.

The Amwell Baptist Church was built in 1834 with Greek Revival style, and remodeled in 1884.