The Wesel–Datteln Canal (German: Wesel-Datteln-Kanal) is a 60-kilometre (37 mi) long canal in North Rhine-Westphalia, Germany.

It runs along the northern edge of the Ruhr Area, from the Rhine near Wesel (51°38′21″N 6°36′25″E / 51.63917°N 6.60694°E / 51.63917; 6.60694) to the Dortmund-Ems Canal near Datteln (51°39′45″N 7°21′58″E / 51.66250°N 7.36611°E / 51.66250; 7.36611).

It forms an important transport connection between the Lower Rhine and northern and eastern Germany, together with the parallel Rhine-Herne Canal.

It runs parallel to the river Lippe.

The canal has six locks, at Friedrichsfeld, Hünxe, Dorsten, Flaesheim, Ahsen and Datteln.