A Omotoso 1997-1999 Mr A. O Ogunmodede 1999- 2004 Mr D. O Ajekigbe(JP) 2004-2005 Mr H. L. T Kolapo 2006-2008 Mr E. O Adepoju 2008- 2010 Mr Oladele I.T 2010-2013 Mrs Okunade J.

Adetona D. A 2017- 2018 Mr. Alabi A. T January 2018 Mr. Awodiran P.A 2018 - 2020 Wesley College of Science (founded as Wesley College on November 5, 1905) is a government controlled, co-educational, senior secondary school located in Ibadan, Oyo State.

[1][2] The school was previously called "Wesley College", a teacher training institution that churned out the like of famous political, elder statesman of repute, and the First Western Premier in the First Republic, Chief Obafemi Awolowo.

Currently known as Wesley College of Science, it educates senior secondary school science students in preparation for Senior School Certificate Examinations.

According to Naij.com, it is the 6th oldest secondary school in Nigeria.