In 2010, Wesley returned to Santos where he became a key player in the 2010 Campeonato Paulista and 2010 Copa do Brasil championship which team won, mostly in the right back position.

His performances at Santos attracted interest from European clubs such as Portuguese side Benfica and German side Werder Bremen[citation needed] In summer 2010, Wesley signed a four-year contract with Werder Bremen for a reported transfer fee of €7.5 million.

[citation needed] On 11 September 2010, he made his debut in a Werder Bremen shirt in a 0–0 draw against Bayern Munich.

On 8 April 2012, he suffered a knee ligament injury in a 3–1 loss against Guarani[13] which kept him out of action for the rest of the season with an expected return in 2013.

[15] Wesley made his début for the Brazil national team on 7 October 2010, as a substitute in a 3–0 friendly win over Iran played at the Zayed Sports City Stadium in Abu Dhabi.