West 21st Street Historic District is a national historic district located at Erie, Erie County, Pennsylvania.

It includes 35 contributing middle and upper class residential buildings built between 1857 and 1939.

They are in a variety of popular architectural styles including Queen Anne, Italianate, and Colonial Revival.

[2] It was added to the National Register of Historic Places in 1990.

This article about a property in Erie County, Pennsylvania on the National Register of Historic Places is a stub.