The historic and endangered[2] Gruwell and Crew General Store is also part of the district.

This change largely occurred around 1900, when wooden storefronts were demolished in favor of ornate commercial blocks.

Shortly after it was built, Nate Crook opened a restaurant and barber shop in a building at 102 W. Main.

The West Branch Bank opened at 104 W. Main in 1875, though it moved across the street three years later.

The 1907 Winery Building, which served as West Branch's post office and later a full-service gas station, collapsed on June 11, 2010.