West College Avenue Historic District is a national historic district located at Hartsville, Darlington County, South Carolina.

The district encompasses 22 contributing buildings in a primarily residential section of Hartsville.

They illustrate a period of significant development which saw the town's population increase more than five times its size at the turn of the 20th century.

The architecture reflects late-19th and early-20th century movements such as Victorian, Queen Anne, Colonial Revival, and Bungalow.

This article about a property in Darlington County, South Carolina on the National Register of Historic Places is a stub.