West Genesee High School offers a wide variety of Advanced Placement Program (AP) courses to its students.

The students receive Syracuse University college credits, but the courses are taught by teachers named adjunct instructors by S.U.

[4] Courses offered through Project Advance include economics, psychology, public affairs, and sociology.

Courses include financial accounting, astronomy, CAD, computer information systems, introduction to business, photography and precalculus.

[5] Students are able to participate in baseball, basketball, bowling, cheerleading, cross-country, football, golf, hockey, lacrosse, soccer, softball, swimming, tennis, track, volleyball, and wrestling.

John Desko, the former head coach of Syracuse University's men's lacrosse team is a former player and alumnus of the school.

In addition to academics and athletics, West Genesee High School also offers a number of clubs and other extracurricular activities.