West Main Street Historic District is a national historic district located at Chesterfield, Chesterfield County, South Carolina.

The district encompasses 13 contributing buildings in a primarily residential section of the town of Chesterfield dating from about 1858 to 1930.

Freedmen of the community built one of the churches in the district in 1878, and it is the only identified ecclesiastical building in Chesterfield to have survived this period.

One early commercial building, now used as apartments, is also included in the historic district.

This article about a property in Chesterfield County, South Carolina on the National Register of Historic Places is a stub.