West Seneca is a centrally located interior town of the county, and a suburb of Buffalo.

West Seneca, Orchard Park and Hamburg form the inner "Southtowns", a cluster of middle-class suburban towns.

Because the town is on land of the former Buffalo Creek Reservation, it was not open to white settlement until the mid-19th century.

In 1909 the area immediately south of Buffalo split from West Seneca, becoming the city of Lackawanna.

[citation needed] The Eaton Site was listed on the National Register of Historic Places in 1979.

The east town line is marked by New York State Route 78 (Transit Road).

[11] XGen Elite Sports Complex is home to the Buffalo eXtreme of the American Basketball Association.

The West Seneca Central School District is the largest and serves the majority of the town.