West Virginia Route 20 is a major north–south state highway in the U.S. state of West Virginia.

The southern terminus of the route is at U.S. Route 52 in Bluewell, a small unincorporated suburb of Bluefield.

The northern terminus is at West Virginia Route 7 three miles (5 km) east of New Martinsville.

WV Route 20 is the longest state route in West Virginia.