Past this interchange, the route becomes a three-lane road with a center left-turn lane and passes businesses in the northern part of Inwood, crossing a Winchester and Western Railroad line.

The road leaves Inwood and continues south-southeast through a mix of fields, woods, and development, curving to the southeast and passing through the community of Tarico Heights.

[1][2] WV 51 crosses Opequon Creek into Jefferson County and continues through a mix of farm fields and woods with some residential and commercial development, curving to the east as it passes north of the community of Middleway.

The road continues east through rural land and passes the community of Aldridge and the historic house Harewood, making a turn to the east-southeast.

WV 51 crosses Norfolk Southern's Hagerstown District railroad line and enters the city of Charles Town, where the name becomes Martin Luther King Jr. Boulevard and the road passes homes.