The southern terminus of the route is at West Virginia Route 2 on the southern outskirts of Ravenswood.

The northern terminus is at Interstate 77/WV 2 exit 179 northeast of Parkersburg.

WV 2, concurrent with I-77 south of this location, departs the expressway and continues north on the same roadway as WV 68.

Before Interstate 77 was completed, State Route 2 followed the Ohio River (more or less) from St. Marys, south through Parkersburg, and on southward along the river to Ravenswood, and further toward Huntington.

It is the only state route in West Virginia that shares a number with an interstate or U.S highway, due to the commissioning of Interstate 68 in 1991.