The SJFA West Region Premiership (also known as the McBookie.com West Region Premiership for sponsorship reasons) was a semi-professional football league run by the West Region of the Scottish Junior Football Association, and was the highest tier of league competition for its member clubs.

The final champions and most successful club were Auchinleck Talbot, who won seven league titles.

From the 2007–08 season, the winners of the league were eligible to enter the senior Scottish Cup at its earliest stage, with Pollok being the first champions to take part in the Scottish Cup.

[1] In 2017 West Region clubs voted to organise all leagues on a regionwide basis and as a result, the Super League Premier Division was rebranded as the West Region Premiership for the 2018–19 season.

Note: Champions in bold completed the 'Double' by also winning the Junior Cup.