ACOA encompasses the provinces of New Brunswick, Newfoundland and Labrador, Nova Scotia, and Prince Edward Island.

In 2014, ACOA assumed responsibility for the direct delivery of economic development programs, services and advocacy in Cape Breton.

To be eligible for this program, the project must be based in Atlantic Canada, have a potential commercial value and include a large R&D component.

The administrative regions served by CED include: Abitibi-Témiscamingue, Bas-Saint-Laurent, Centre-du-Québec, Chaudière-Appalaches, Côte-Nord, Estrie, Gaspésie–Îles-de-la-Madeleine, Lanaudière, Laurentides, Laval, Mauricie, Montérégie, Montréal, Nord-du-Québec, Outaouais, Québec, and Saguenay–Lac-Saint-Jean.

While a lot of progress has been made in achieving FedNor's objectives, communities in Northern Ontario continue to face the ongoing economic challenges that necessitate a stable, long-term regional development effort.

The Minister responsible for this agency was originally called the "Minister responsible for the Federal Economic Development Initiative for Northern Ontario" In 2020, FedNor invested over CA$122 million in 294 initiatives led by local businesses, organizations, and communities, helping to support over 7,300 jobs in Northern Ontario.

[24] Since its creation in 2009 to October 1, 2021, FedDev Ontario has invested more than $3.5 billion in over 5,000 projects working with over 63,000 organizations and businesses that have generated strong results, such as supporting nearly 190,000 jobs in the region.

Its area of operations is in the 37 census divisions of Statistics Canada, from Cornwall in the east to Owen Sound in the west, and from Pembroke in the north to Windsor in the south.

[26] It was created in August 2021 from splitting the Western Economic Diversification Canada into two separate agencies, the other encompassing the Canadian Prairies.

[27][30] It will also be establishing new service locations in Lethbridge, Fort McMurray, and Grande Prairie, Alberta; Regina and Prince Albert, Saskatchewan; and Brandon and Thompson, Manitoba.

[31] PrairiesCan was created in August 2021 from splitting the Western Economic Diversification Canada into two separate agencies, the other encompassing British Columbia.

[29][27] On 5 August 2021, the Government of Canada announced that WD would be divided into two new agencies—PacifiCan for BC; and PrairiesCan for Alberta, Manitoba, and Saskatchewan.

WD was headquartered in Edmonton, AB, and had regional offices in each of the other western provinces: Winnipeg, MB; Saskatoon, SK; and Vancouver, BC.