[7] The last natural species habitats are in vegetated beach dune scrub, low heath and hummock grasslands.

[5] The Western barred bandicoot are known as solitary omnivorous animal, foraging on their own,[5] eating plant matter, invertebrates and skinks.

[12] However the species was successfully reintroduced into the fenced Arid Recovery Reserve at Roxby Downs, South Australia in 2000, and to Faure island, Shark Bay in 2005.

[16] In September 2023, the species was released at two large fenced reserves within New South Wales; in the Pilliga Forest and Mallee Cliffs.

[19] The disease is known to occur only in adult Western barred bandicoots, with the average onset recorded from 3 years and 2 months with lesions increasing in size until they become debilitating.

[20] There are records of predation by the native Gould's monitor (Varanus gouldii)[7] and the western quoll (Dasyurus geoffroii).

[12] Introduced rabbits are not a predator, however they out-compete and modify the vegetation required for food and habitat of the Western barred bandicoot.

[10] A fence designed to exclude foxes and feral cats was constructed across a narrow neck of Heirisson Prong in 1990, intended to protect a 1200 ha area at the tip of the peninsula from exotic predators.

[12] Feral cats were believed primarily responsible for the local extinction of western barred bandicoots on Heirisson Prong in 2008.

[10] A fence designed to exclude foxes and feral cats was constructed across a narrow neck of Heirisson Prong in 1990, allowing a 1,200 hectares (3,000 acres) area of the tip of the peninsula to be rid of exotic predators.

Diversity losses of genetic drifting due to island bottle necking are likely to counteract the fitness of the species, leaving them vulnerable to diseases, which is already evident.