Weston Manor is an 18th-century plantation house on the south shore of the Appomattox River in Hopewell, Virginia.

William and Christian Eppes Gilliam built their home, Weston Manor, in 1789 on land in Prince George County that was acquired two years earlier from her cousin John Wayles Eppes.

By the late 18th century through hard work and smart marriages the family had amassed several plantations in the area.

Weston Manor is listed on the National Register of Historic Places.

This article about a property in Hopewell, Virginia on the National Register of Historic Places is a stub.