Wetsel is an unincorporated community in Collin County, located in the U.S. state of Texas.

Henry Wetsel, a prominent McKinney merchant and early settler, is honored by the community's name.

Wetsel eventually sold his holdings in McKinney and headrighted a square mile of land south of the town.

Wetsel had built and run an early grist and flour mill in the county seat.

[2] Wetsel is located inside the Allen city limits, 5 mi (8.0 km) southwest of McKinney in southwestern Collin County.