The closest village, at a distance of less than a kilometre to Wetsinge is Sauwerd.

The first occupation of the mound of Groot Wetsinge dates from the 3rd century BC.

Several discoveries have been made in the wierde, including an earthen lamp from the first century BC.

The detached gothic clock tower, which appears on the map of Joannes Baptista Regemortes from 1643 or 1644, was probably built in the 13th or 14th century southeast of the church, when more detached church towers were built in Groningen.

It was replaced the same year by a church built halfway between Wetsinge and Sauwerd.