The motto for the school is Palman Qui Meruit Ferat which means "Let him bear the palm who has deserved it".

[citation needed] Located on Pharmacy Avenue in Scarborough, Wexford is a mid-sized, three storey secondary school.

The origins began when the Scarborough Board of Education applied for accommodation for a 1200 pupil secondary school named Northwest Collegiate Institute on April 2, 1962 and took steps to acquire the 8.59 acre farm owned by the late William Henry McGuire.

For students that geographically reside in Wexford's catchment area, the general TDSB admission policies apply for the regular academic program.

[3] In May 2022, the Student Interest Programs Policy[4] was approved by the TDSB Board of Trustees following "extensive consultation and feedback from students, parents/guardians, staff, and the broader community, as well as a review of best practices, system data, and TDSB enrolment trends."

The purpose of the new policy is to "improve access and remove long-standing barriers" to specialized programs in TDSB secondary schools.

Per the new policy, auditions, formal portfolios, entrance exams, and report card marks will no longer be used to select and accept applicants to specialized programs in TDSB secondary schools such as the Performing or Visual Arts programs at WCSA.

In the 1990s, Wexford established a great relationship between the Music Theatre students and the Hospital for Sick Children's Telethon produced by CFTO.

In 1993 they had four "spots" on the telethon, including the final number which they shared with Colm Wilkinson (The Phantom) and Michael Burgess (Les Miz, Man of La Mancha).

The Music Theatre students also performed in a video with Donny Osmond (Joseph and the Amazing Technicolor Dream Coat) and in 1994 shared the stage with Michael Bell (Show Boat).

[6] In 2012, the Wexford Gleeks placed second in the SCC Nationals, but were the audience favorite as the only choir to receive two standing ovations during the competition.

In February 2013, the Wexford Gleeks recorded a song with an extraterrestrial Chris Hadfield and Ed Robertson of the Barenaked Ladies.

Hadfield, astronaut and amateur musician, was circling the earth on the International Space Station at the time of the recording.