Weymouth and Melcombe Regis was a parliamentary borough in Dorset represented in the English House of Commons, later in that of Great Britain, and finally in the Parliament of the United Kingdom.
On petition the result was overturned on 4 April 1842 and the opponents, Bernal and Christie, were seated in their place.
Christie resigned by accepting the office of Steward of the Chiltern Hundreds, causing a by-election.
In the Aubrey-Maturin novels by Patrick O'Brian the constituency of Melcombe in Dorset is the Parliamentary seat for Jack Aubreys father who holds it for the Whigs.
On his father's death Jack Aubrey is offered and takes up the seat for the Tories.