The name of the game refers to internet memes and is a play on the phrase what do you mean.

[1] The game was created by Elliot Tebele and Ben Kaplan in 2016.

A judge, called "The Jerry", chooses the funniest caption card out of all those submitted during that round, and whoever had submitted it is the champion of the round.

[4] What Do You Meme sells themed expansion packs.

[4] The game has partnered with various brands to launch expansion packs such as the SpongeBob SquarePants Family Edition.