The women's singles wheelchair tennis tournament at the 2020 Paralympic Games in Tokyo is held at the Ariake Tennis Park in Kōtō, Tokyo from 28 August and 3 September 2021.

[1] The reigning champion was Jiske Griffioen, who was not defending her title, having retired in 2017.

[2] Diede de Groot succeeded in the fourth leg of a Golden Slam, having won the Australian Open, French Open and Wimbledon earlier in the year.

[3] Click on the seed number of a player to go to their draw section.