For much of the Civil War, he served as the senior cavalry general in the Army of Tennessee and fought in most of its battles in the Western Theater.

Within this interchange, the road enters Richmond County (and the city limits of Augusta) and curves to the southeast.

Just southeast of the hospital is an intersection with both the southern terminus of Medical Center Drive, which leads to the hospital itself, and the northern terminus of Augusta West Parkway, which mostly serves as a frontage road for the western side of I-520 (Bobby Jones Expressway).

On the eastern side of the interstate is an intersection with the southern terminus of Robert C. Daniel Jr. Parkway and the northern terminus of Marks Church Road, the latter serving as a frontage road for the eastern side of I-520.

Wheeler Road skirts along the southern edge of Big Oak Park and Westover Memorial Cemetery.